Correlation of Matrix Metalloproteinase-2 and p21 Expressions with Capsular Invasion of Thymoma AB

Thymomas are the common neoplasms of mediastinum, and type AB is most frequent case. All thymomasare potential for invasion to adjacent tissues considered malignant. Capsular one itsprognostic indicators. Matrix metalloproteinase-2 (MMP-2) a family proteinases that has abilityto degrade component extracellular matrix affect tumor or metastasis. Cytoplasmicexpression p21 protein can be significantly correlated with The correlation thesetwo proteins in thymoma not been widely studied, hence we aimed analyze expression MMP-2and investigate their capsular AB. This cross-sectional studywas performed on 24 paraffin-embedded samples thymomectomy during January 2013-Desember2019 at Anatomical Pathology Laboratory Dr. Soetomo General Hospital Surabaya. weredevided based into 2 groups. Immunohistochemical staining was detectexpression MMP-2. statistically analyzed using Spearman test. There wasno significant difference MMP-2 between withoutcapsular (p=0.839), also no withcapsular without (p=0.816). No expressionsin revealed (p=0.255). In AB, were notcorrelate invasion. These results may contribute development research.